Subject(s)
Humans , History, 20th Century , History, 21st Century , Diabetes Mellitus/history , Insulin/history , Uruguay , BrazilABSTRACT
Nos últimos anos, os avanços nas descobertas da terapêutica para o DM2 entusiasmaram os clínicos e especialistas no que diz respeito à redução dos eventos cardiovasculares, internações e mortalidade. Outros estudos ainda estão em andamento e prometem fortalecer a expectativa de mudança nos desfechos cardiovasculares dessa população. O objetivo dessa revisão consiste em reunir os principais estudos clínicos que demonstraram a segurança e/ou redução na ocorrência de eventos cardiovasculares com uso de fármacos anti-hiperglicemiantes.
In recent years, breakthroughs in therapeutic findings for DM2 have encouraged physicians and specialists with regards to the reduction of cardiovascular events, hospitalization and mortality. Other studies are underway, and promise to strengthen the prospects of change in cardiovascular outcomes for this population. The goal of this review is to bring together the most important clinical trials that have demonstrated safety and/or a decrease in cardiovascular events with the use of antihyperglycemic drugs.
Subject(s)
Humans , Cardiovascular Diseases/diagnostic imaging , Diabetes Mellitus/drug therapy , Insulin/history , Metformin/history , Liraglutide/administration & dosage , Hypoglycemic Agents/economics , Hypoglycemic Agents/adverse effectsSubject(s)
History, 19th Century , History, 20th Century , Endocrinology/history , Physiology/history , Insulin/history , RomaniaSubject(s)
Biochemistry/history , Canada , Diabetes Mellitus/history , History, 19th Century , History, 20th Century , Humans , Insulin/history , Nobel Prize , Ontario , Philately/historyABSTRACT
The discovery of the insulin which took place at Toronto, Canada in 1921-22 is one of the most important medical discoveries of the modern age. For this miracle, Prof. John James Macleod and Frederic Grant Banting were Jointly awarded the Nobel Prize in 1923 for Physiology or Medicine. Frederick Sanger a British biochemist discovered the structure of insulin in 1958 and was awarded Nobel prize for chemistry. Diabetes mellitus is called Madhumeha in ancient Indian Ayurvedic medicine. Egyptians and Greeks knew about it. Greek physician Aretaeus of Capadocia first suggested the term "Diabetes" and described it. Though insulin was discovered about 80 years ago research interest in it still continues unabated. This paper also gives case details of the first patient on whom Insulin was first tried and chronology of research on pancreas and Insulin.
Subject(s)
Canada , Diabetes Mellitus/history , History, 19th Century , History, 20th Century , History, Ancient , History, Early Modern 1451-1600 , History, Medieval , History, Modern 1601- , Insulin/historySubject(s)
Humans , Carbohydrates/history , Carbohydrates/metabolism , Diabetes Mellitus/diet therapy , Diabetes Mellitus/genetics , Diabetes Mellitus/history , Diabetes Mellitus/mortality , Diabetes Mellitus/physiopathology , Glucose Intolerance/history , Insulin/history , Islets of Langerhans , Pancreas Transplantation/history , Diabetic Nephropathies , Sulfonylurea Compounds/therapeutic useSubject(s)
Animals , Diabetes Mellitus/drug therapy , History, 19th Century , History, 20th Century , Humans , Insulin/historyABSTRACT
Se hace un breve recuento histórico de la evolución de los diferentes preparados insulínicos utilizados en el tratamiento de la diabetes mellitus, desde el descubrimiento de la insulina en 1921 por Banting y Best, hasta la obtención de una insulina idéntica estructuralmente a la insulina humana por métodos sintéticos
Subject(s)
Humans , History, 20th Century , Insulin/historyABSTRACT
En este trabajo se dan a conocer las perspectivas de desarrollo que se preveen para los próximos años en la Industria Médico-Farmacéutica, específicamente en la producción opoterapéutica (insulina, heparina pepsina). Además se explican las experiencias obtenidas en el Laboratorio Farmacéutico "Mario Muñoz", en las pruebas tecnolólicas llevadas a cabo, así como las ventajas económicas que representa para el país el aprovechamiento de los recursos naturales disponibles